Study on photo-damage selectivity in photodynamic therapy by means of Monte Carlo method
-
Corresponding author:
HE Qing-li, heqngli@nwu.edu.cn
-
Received Date:
2007-01-05
Accepted Date:
2007-03-14
-
Abstract
The purpose is to provide insight into the issue of photo-damage selectivity in photodynamic therapy.Monte Carlo simulation was performed using different optical property for normal and tumor tissue.The decay of photodynamic dose with depth was approximately exponential.The greater depth of effect of increasing photodynamic dose obtainable in the tumor/normal simulation is clear as the greater depth of completely selective damage is,which has a threshold photodynamic dose for tissue necrosis and is affected by the photo spot size.For typical photosensitizer retention ratios,it is possible to obtain a shallow but entirely selective depth of tumor necrosis,but to obtain deeper tumor necrosis necessarily means some degree of normal tissue damage.
-
-
References
|
[1]
|
LI Zh H,LAI J Ch,WANG Zh D,et al.The application of impulse response function in Monte Carlo simulation of light distribution in biological tissues[J].Laser Technology,2001,25(4):263-267(in Chinese). |
|
[2]
|
LI H W,JACQUES S L,LI Q Zh.MCML-Monte Carlo modeling of light transport in multi-layered tissues[J].Computer Methods and Programs in Biomedicine,1995,47(2):132-133. |
|
[3]
|
PATTERSON M S,WILSON B C,GRAF R.In vivo tests of the concept of photodynamic dose in normal rat liver photosensitised by aluminium chlorosulphated phthalocyanine[J].Photochemistry and Photobiology,1990,51(3):343-349. |
|
[4]
|
de JODE M L.Monte Carlo simulation of light distribution in an embedded tumor model:studies of selectivity in photodynamic therapy[J].Lasers in Medical Science,2000,15(1):49-56. |
|
[5]
|
WILSON B C,PATTERSON M S,BURNS D M.Effect of photosensitizer concentration in tissue on the penetration depth of photoactivating light[J].Lasers in Medical Science,1986,1(4):235-244. |
|
[6]
|
GOMER C J,DOUGHERTY T J.Determination of[3H] -and[14C] hematoporphyrin derivative distribution in malignant and normal tissue[J].Cancer Research,1979,39(1):146-151. |
|
[7]
|
RIS H B,ALTERMATT H J,NACHBUR B,et al.Effect of drug light interval on photodynamic therapy with meta-tetrahydroxyphenylchlorin in malignant mesothelioma[J].International Journal of Cancer,1993,53(1):141. |
-
-
Proportional views
-
Map
DownLoad: