Study on dosimetry during photodynamic therapy

XU Zhao-hui; CHENG Quan; ZHI Lian-he

doi:10.3969/j.issn.1001-3806.2011.04.026

Based on the mathematical model of photodynamic-damage dose in tumor and the function of photodynamicdamage dose with light dose,photosensitizer dose and oxygen concentration,the relationship of effective absorbed dose of light and photosensitizer changed with oxygen concentration was studied,then the photodynamic-damage effects of K562 cells on different medicine(light and photosensitizer) dose was presented.It is found that there is an optimal therapeutic dose during photodynamic therapy (PDT)and its size related with oxygen concentration,the severer the hypoxia,the smaller the optimal photodynamic dose and the less the tumor is damaged.In experiments it was found that the optimal dose in K562 cells suspension was 20 ×0.25 (J/cm2×mmol/L) when the photodynamic damage effect was best.It is shown that tumor can be damaged selectively in PDT and it provides a theoretical support for PDT to be widely used in clinics.

Study on dosimetry during photodynamic therapy

Corresponding author: XU Zhao-hui, xuzhaohui1978@163.com;

1. Department of Physics, Zhoukou Normal University, Zhoukou 466001, China

Received Date: 2010-10-13

Accepted Date: 2010-12-27

Available Online: 2011-07-25

Abstract: Based on the mathematical model of photodynamic-damage dose in tumor and the function of photodynamicdamage dose with light dose,photosensitizer dose and oxygen concentration,the relationship of effective absorbed dose of light and photosensitizer changed with oxygen concentration was studied,then the photodynamic-damage effects of K562 cells on different medicine(light and photosensitizer) dose was presented.It is found that there is an optimal therapeutic dose during photodynamic therapy (PDT)and its size related with oxygen concentration,the severer the hypoxia,the smaller the optimal photodynamic dose and the less the tumor is damaged.In experiments it was found that the optimal dose in K562 cells suspension was 20 ×0.25 (J/cm2×mmol/L) when the photodynamic damage effect was best.It is shown that tumor can be damaged selectively in PDT and it provides a theoretical support for PDT to be widely used in clinics.

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Reference (8)

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Study on dosimetry during photodynamic therapy

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References

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