High-speed and 128-channel multi-spectral photoacoustic tomography system for small animal

LI Hui; CAO Yu; LIU Hongbo; PENG Dong; ZHU Yukun; WANG Kun; TIAN Jie

doi:10.7510/jgjs.issn.1001-3806.2017.05.010

LASER TECHNOLOGY > 2017 > 41(5): 669-674. > DOI: 10.7510/jgjs.issn.1001-3806.2017.05.010

LI Hui, CAO Yu, LIU Hongbo, PENG Dong, ZHU Yukun, WANG Kun, TIAN Jie. High-speed and 128-channel multi-spectral photoacoustic tomography system for small animal[J]. LASER TECHNOLOGY, 2017, 41(5): 669-674. DOI: 10.7510/jgjs.issn.1001-3806.2017.05.010

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High-speed and 128-channel multi-spectral photoacoustic tomography system for small animal

1.
School of Automation, Harbin University of Science and Technology, Harbin 150080, China
2.
Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

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Received Date: November 22, 2016
Revised Date: December 27, 2016
Published Date: September 24, 2017

Graphical Abstract

Abstract

Abstract

In order to achieve high-speed acquisition and real-time high-quality image reconstruction of photoacoustic tomography signals for small animal, a 128 element arc-shaped focused ultrasound transducer with 270° coverage angle, four 32 channel NI data acquisition modules, a tunable pulsed laser and model-based photoacoustic tomography reconstruction algorithm with regularized optimization were used. The spatial resolution of the system can be up to 180μm. The in vitro and in vivo imaging experiments show that the system can complete photoacoustic tomography data acquisition within 1ms, and obtain high quality reconstructed images within 40s. The system can be used to carry out in vivo multi-spectral photoacoustic tomography of small animals.
- biotechnology,
- photoacoustic tomography,
- multi-element arc-shaped focusing transducer,
- high-speed multi-channel,
- multispectral

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References

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