Abstract: In order to study the process of cutting carbon fiber reinforced plastics (CFRP) with 100W picosecond laser, theoretical analysis and experimental verivication were carried out by vaying a single affeting factor. Effect of average power, pulse repetition rate, scanning speed and number of repeat on the heat affected zone and scanning depth were studied. A piece of 1.5mm thick CFRP was cut in experiments. The results show that the cutting line and circular hole with almost no heat affected zone were obtained under the conditions of average power 60W, repetition rate 0.4MHz, scanning speed 10m/s, number of repeat 20 and upper surface width of the kerf 350μm. The study provides some reference for further academic research and industrial application of picosecond laser cutting CFRP.