Study on terahertz absorption characteristics of ischemic rat brain tissue

ZHANG Zhang; MENG Kun; ZHU Liguo; CHEN Tunan; LI Zeren; FENG Hua; LING Furi; YAO Jianquan

doi:10.7510/jgjs.issn.1001-3806.2016.03.015

In order to explore the absorption features of rat brain tissue at different ischemia time, the model of middle cerebral artery occlusion was established and terahertz time-domain spectroscopy of ischemic rat brain tissue was measured. After theoretical analysis and experimental evaluation, terahertz absorption coefficient of ischemic brain tissue at different time in the frequency band from 0.4THz to 0.95THz was acquired. The results show that different absorption characteristics to terahertz wave at different time of ischemic brain tissue is due to intermediates, such as excitatory amino acids produced by ischemia brain injury cascade, lactic acid produced by anaerobic respiration, and large quantities of nitric oxide synthesis produced by calcium overload. The results will have an important role in studying the pathology mechanisms of ischemic brain injury and have a certain value in the biomedical field.

Study on terahertz absorption characteristics of ischemic rat brain tissue

Corresponding author: LING Furi, lingfuri@163.com;

1. School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China;

2. Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang 621900, China;

3. Southwest Hospital, Chongqing 400038, China;

4. Department of Opto-electronics Information Engineering, School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China

Received Date: 2015-01-27

Accepted Date: 2015-04-30

Available Online: 2016-05-25

Abstract: In order to explore the absorption features of rat brain tissue at different ischemia time, the model of middle cerebral artery occlusion was established and terahertz time-domain spectroscopy of ischemic rat brain tissue was measured. After theoretical analysis and experimental evaluation, terahertz absorption coefficient of ischemic brain tissue at different time in the frequency band from 0.4THz to 0.95THz was acquired. The results show that different absorption characteristics to terahertz wave at different time of ischemic brain tissue is due to intermediates, such as excitatory amino acids produced by ischemia brain injury cascade, lactic acid produced by anaerobic respiration, and large quantities of nitric oxide synthesis produced by calcium overload. The results will have an important role in studying the pathology mechanisms of ischemic brain injury and have a certain value in the biomedical field.

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Reference (17)

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Study on terahertz absorption characteristics of ischemic rat brain tissue

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