Thermal change on optical penetration depth in human prostatic hyperplasia tissue in vitro
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摘要: 为了研究热作用下人良性前列腺增生(BPH)组织对532nm,670nm,830nm和1064nm的光穿透深度的变化及其差异。采用了双积分球测量系统以及反向倍增法获取组织的光学特性。得到的实验结果为:在20℃~80℃的温度范围内,BPH组织对532nm,670nm,830nm和1064nm的光穿透深度都是随着激光波长的增大而增大,随着热作用温度的变化而改变的。随着热作用温度的升高,BPH组织对1064nm的光穿透深度的变化显著地较其对532nm,670nm,830nm的光穿透深度的变化都要大得多。其对532nm,670nm,830nm和1064nm的光穿透深度的最大值分别在50℃,50℃,50℃和70℃,其值分别为0.404mm,0.539mm,0.699mm和5.917mm;最小值分别在20℃,20℃,80℃和60℃,其值分别为0.251mm,0.449mm,0.621mm和1.542mm。该测量结果可为激光的光热治疗BPH提供一点有益的参考。Abstract: Thermal change and its difference on the optical penetration depth of human benign prostatic hyperplasia(BPH) tissue was measured with a double-integrating-sphere setup at 532nm,670nm,830nm and 1064nm. The optical properties of BPH tissue were assessed from the measurement results using the inverse adding-doubling method.The results of measurement showed that,in exposure temperature range from 20℃ to 80℃,the optical penetration depth of BPH tissue at 532nm,670nm,830nm and 1064nm increased with increase of wavelengths,the optical penetration depth of BPH tissue at 532nm,670nm,830nm and 1064nm varied with a change of exposure temperature by thermal effect,change of the optical penetration depth of BPH tissue at 1064nm was significantly bigger than that of BPH tissues at 532nm,670nm and 830nm,respectively with increase of exposure temperature.Maximal optical penetration depths of BPH tissue at 532nm,670nm,830nm and 1064nm were respectively 0.404mm,0.539mm,0.699mm and 5.917mm at exposure temperature of 50℃,50℃,50℃ and 70℃,respectively,andminimal optical penetration depths were respectively 0.251mm,0.449mm,0.621mm and 1.542mm at exposure temperature of 20℃,20℃,80℃ and 60℃.The results of measurement indicated a few useful reference data for treatment of BPH using optical and thermal properties of laser.
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