Abstract: Laser drilling can significantly improve cigarette quality, such as total ventilation rate and draw resistance of cigarettes and satisfy consumers' sensory experience. In order to obtain the best combination of laser drilling parameters, the relationship equation between laser drilling parameters and draw resistance was explored by using full factor experiment method on the premise of the fixed absorption index. The results show that pulse width is more significant than the other two factors (power and offset hole size). When the three factors change one unit at the same time, pulse width contributes the most influence on draw resistance, about 10 times that of power and offset hole size. In order to reduce draw resistance, the three main factors should be as large as possible. The interaction between power and offset hole size is more significant than the interaction among other factors. The study provides statistical basis for quality control of draw resistance, and the method of analyzing problems also provides the reference for other similar experiments.