Abstract: In order to solve the problem of large amount of data, high complexity and long time consuming in traditional digital image processing algorithm, a method for center location of optical fiber spot was presented based on field-programmable gate array (FPGA). By using digital signal processing system and development tools (DSP builder), image preprocessing algorithm and edge detection algorithm were designed. The least square method was used to fit the boundary of light spot. The parallel capability for data processing was enhanced and the processing speed was improved by means of pipeline design. Theoretical analysis and experimental verification were carried out on Cyclone V platform. The image boundary and the central coordinate data were obtained. The results show that under the condition that the absolute error of spot center location is less than 0.1pixel, the computer speed can be improved by more than 21 times based on FPGA. The spot center can be located quickly and accurately on FPGA platform.