Abstract: In order to determine the optimal parameters for three-coordinate laser measurement, and get better measurement effect, theoretical analysis and experimental verification were conducted based on the orthogonal test. The best performance could be achieved under the conditions of speed at the tenth fastest set, frequency at 30Hz, optimum depth-of-field and angle perpendicular to the surface of the workpiece. The results show that it becomes easy to choose parameters in the three-coordinate laser measurement, after qualitative analysis and quantitative analysis.