DMTU对激光视网膜损伤治疗作用的实验研究

Experimental research of protective effects of dimethylthiourea in the rabbit retina laser injury

摘要: 二甲基硫脲(DMTU)是一种特异的自由基清除剂,实验中,建立了动物视网膜激光损伤模型,观察了治疗组与对照组不同时间点视网膜的组织病理改变以及生化和分子生物学指标的变化。结果表明,DMTU可以有效地抑制感光细胞的脂质过氧化,能明显减少损伤区域视网膜神经元的凋亡数目,保护视网膜组织的结构和形态。

Abstract: Dimethylthriourea(DMTU) is an effective free radical scavenger.Through investigation of histopathological and biochemical changes,we have obseved the effects of DMTU on rabbit retina in laser injury.The results show that photoreceptor cells die mainly of apoptosis in laser-induced retina degeneration and DMTU demonstrate the neropotective effect due to inhibition of lipid peroxidation.