Abstract: A comparison of acute ocular damages of rabbit eyes induced by the coupling cavity injection mode-locked Nd:YAG laser picosecond pulse train and its doubled frequency 0.53μm pulse train and nanosecond pulse train using solid color centre crystal mode-locked was reported.The result showed that the ocular damages(ED50) was 83.5μJ at 1.06μm for mode-locked picosecond laser pulse train;the energy required to produce lesions in 40% events was 62.2μJ at 1.06μm and 6.1μJ at 0.53μm,ratio 10:1,and the dose required in 83.3% events,for nanosecond and picosecond laser pulse train,was 1190μJ and 260μJ at 1.06μm,ratio 5:1 approximately.