Abstract: In order to measure curvature radius of laser wavefront accurately, one method based on Talbot-Moire fringe technique was proposed. The theoretical model of measuring wavefront curvature radius was established. The relationship between wavefront curvature radius and angle of Moire fringe, and the measurement uncertainty of the system were analyzed. The measurement system was designed and constructed. Wavefront curvature radius of laser system with the diameter of 200mm was measured. The results show that, the repeatability of measurement is 0.2% when the measured result is 498m. The relative deviation between the waist position and the actual position of the beam is 0.4%. According to the measured results of 500m~3000m, the parameters such as wavefront curvature radius, the focal length of object and the position of eyepiece are calibrated. After calibration, the maximum deviation from the theoretical value is 2%. The method can achieve high precision measurement of wavefront curvature radius of laser launching system with large aperture.