Abstract: In order to obtain technological parameters for cleaning tire molds with laser, a self-developed pulse YAG laser with the average power of 250W was used to carry out experiment of tire mold cleaning. The experimental data of the relationship between different laser parameters and the cleaning effect of the tire mold was obtained. The relationships between the parameters such as laser peak power, energy density and cleaning speed, cleaning effect of the tire mold were studied. The results show that for cleaning tire molds, pulse YAG laser is more efficient than CO₂ laser. Laser energy density threshold for cleaning tire molds is about 250mJ/mm². The increase of laser peak power and average power can improve cleaning speeds and cleaning effect. The research provides the reference for research of laser cleaning equipment in this field.