Abstract: In order to optimize the process parameters in laser welding of high-strength galvanized steel with powder filling, orthogonal experimental tests were used to analyze such process parameters as laser power, welding speed and the defocusing distance. The test results show that the accumulation of the molten mass and the welding holes might occur at low welding speed; the defocusing distance should be increased to achieve the effective addition of the powder. The optimization process parameters for laser welding of high-strength galvanized steel with powder filling were 1500W laser power, 30mm/s welding speed and 12mm defocusing distance. Under these welding conditions, good weld performance was obtained and the base material was broken in tensile fracture tests.