The development of light emitting diode therapy in biology and medicine

CUI Hong-zhong; LI Zheng-jia; FAN Xiao-hong

Volume 30 Issue 6

Sep. 2013

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The development of light emitting diode therapy in biology and medicine

1.
Laser Medical Laboratory, Institute of Laser Technology and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Corresponding author: LI Zheng-jia, zhjl@imail.hust.edu.cn ;
Received Date: 2005-11-01
Accepted Date: 2006-01-26

Abstract

The application of light emitting diode(LED) therapy in biology and medicine is summarized,which focuses on the experiments in animal model,animal cells and clinical research.The advantages and disadvantages of LED therapy are compared with those of the other light sources in the view of safety,reliability and low cast.It can be sure that LED therapy must have a wide foreground in biology,medicine and commercial products.
- medical optics and biotechnology,
- light emitting diode therapy,
- light emitting diode,
- clinical,
- photodynamic therapy,
- biostimulation,
- animal

References

[1]	KARU T I,PYATIBRAT L V,KALENDO G S.Cell attachment modulation by radiation from a fulsed light(λ=820 nm)and various chemicals[J].Lasers in Surgery and Medicine,2001,B28(9):227～236.
[2]	STEVE Y,PETER B,DYSON M.Macrophage responsiveness to light therapy[J].Lasers in Surgery and Medicine,1989,31 (3):497～505.
[3]	WHELAN H T,SMITI R L,BUCHMAN E V et al.Effect of NASA light-emitting diode irradiation on wound healing[J].Journal of Clinical Laser Medicine and Surgery,2001,19(6):305～341.
[4]	WHELAN H T,BUCHMANN E V,WHELAN N T et al.NASA light emitting diode medical applications from deep space to deep sea[A].Space Technology and Applications International Forum[C].Melville,New York:American Institute of Physics,2001.35～45.
[5]	WHELAN H T,SCHMIDT M H,SEGURA A D et al.The role of photodynamic therapy in posterior fossa brain tumors:a pre-clinical study in a canine glioma model[J].Journal of Neurosurgery,1993,79(4):562～568.
[6]	WHELAN H T,MARGARET T T,RILEY W et al.DARPA soldier self care:rapid healing of laser eye injuries with light emitting diode technology[A].RTO HFM Symposium[C].Northern Mariana Islands:Trauma Technology and Emergency Medical Procedures,2004.19～37.
[7]	WHELAN H T,HOULE J M,DONOHOE D L et al.Medical applications of space light-emitting diode technology-space station and beyond[A].Space Technology and Applictions International Forum[C].Melville,Yew York:American institute of Physics,1999.3～15.
[8]	LI Y,LIU T C Y,DUAN R et al.Effects of some anesthetics on wound healing:laser biomodulation mechanism[J].Lasers in Surgery and Medicine,2001,S13(7):7～15.
[9]	DUAN R,ZHU L,LIU T C Y et al.Light emitting diode irradiation protect against the amyloid beta 25-35 iduced apoptosis of PC12 cell in vitro[J].Lasers in Surgery and Medicine,2003,33 (3):199～203.
[10]	VREMAN H J,STEVENSON D K.Devices for treating circadian rhythm disorders using LED's[P].U S Patent:6350275,2002-09-15.
[11]	FRENKEL R E,FRENKEL B G.Quantifying stress reduction and medical treatment as a result of colored light therapies[P].U S Patent:6007569,1999-07-13.
[12]	VREMAN H J,SEIDMAN D S,STEVENSON D K.Phototherapy of jaundiced newborns using garments containing semiconductor lightemitting devices[P].U S Patent:6596016,2003-06-22.
[13]	ZHANG Ch M,WANG J,DU L Zh.Blue light source in phototherapy[J].Journal of Zhejiang University(Medical Sciences),2002,31 (3):222～224(in Chinese)
[14]	SCHLAGER K J.Immunophototherapy for the treatment of cancer of the larynx[J].SPIE,1993,1891:148～159.
[15]	XU Ch Sh,LEUNG W N.Study of hypericin-mediated photodynamic therapy on human nasopharyngeal carcinoma cell[J].Laser Technology,2005,29(4):395～397 (in Chinese).
[16]	MESTER E,SPIRY T,SZENDE B et al.Effect of laser rays on wound healing[J].The American Journal of Surgery,1971,22(8):532～535.
[17]	SCHMIDT M H,BAJIC D M,REICHERT K W et al.Light-emitting diodes as a light source for intra-operative photodynamic therapy[J].Neurosurgery,1996,38 (3):552～556.
[18]	FRANKA S,STEPHEN H A,KLAUS D J et al.Light-emitting diode (LED) polymerisation of dental composites:flexural properties and polymerisation potential[J].Biomaterials,2000,21 (5):1379～1385.
[19]	PERRICONE N V.Skin treatments using blue and violet light[P].U S Patent:20030009158A1,2003-07-22.
[20]	ELLA S.System and method for facial treatment[P].U S Patent:20030032900A1,2003-02-02.
[21]	ROBERT A W,DAVID H M,ROY G G et al.Clinical trial of novel non-thermal LED array for reversal of photoaging:clinical,histologic,and surface profilometric results[J].Lasers in Surgery and Medicine,2005,36(7):85～91.
[22]	STREETER J.Low level light therapy for the treatment of myocardial infarction[P].U S Patent:20030212442A1,2003-05-23.
[23]	STREETER J.Low level light therapy for the treatment of stroke[P].U S Patent:20030109906A1,2003-03-11.
[24]	SCHLAGER K J,LGNATIUS R W.An LED-array light source for medical therapy[J].SPIE,1994,2131:341～353.
[25]	LIU J,LIU T C Y.The applications and prospects of light emitting diodes in biology and medicine[J].Laser Journal,2002,23 (6):1～4(in Chinese).
[26]	LIU J,LIU T C Y,FAN G H.The light emitting diode (LED) instrument of low intensity irradiation of cellor tissue culture[J].Laser Journal,2003,24(4):78～80(in Chinese).
[27]	LIU J,FAN G H,LIU T C Y et al.The light emitting diode(LED) instrument of high intensity irradiation of cellor tissue culture[J].Acta Laser Biology Sinica,2003,12(4):308～314(in Chinese).

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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The development of light emitting diode therapy in biology and medicine

Corresponding author: LI Zheng-jia, zhjl@imail.hust.edu.cn;

1. Laser Medical Laboratory, Institute of Laser Technology and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Received Date: 2005-11-01

Accepted Date: 2006-01-26

Available Online: 2006-11-25

Abstract: The application of light emitting diode(LED) therapy in biology and medicine is summarized,which focuses on the experiments in animal model,animal cells and clinical research.The advantages and disadvantages of LED therapy are compared with those of the other light sources in the view of safety,reliability and low cast.It can be sure that LED therapy must have a wide foreground in biology,medicine and commercial products.

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Reference (27)

[1]	KARU T I,PYATIBRAT L V,KALENDO G S.Cell attachment modulation by radiation from a fulsed light(λ=820 nm)and various chemicals[J].Lasers in Surgery and Medicine,2001,B28(9):227～236.
[2]	STEVE Y,PETER B,DYSON M.Macrophage responsiveness to light therapy[J].Lasers in Surgery and Medicine,1989,31 (3):497～505.
[3]	WHELAN H T,SMITI R L,BUCHMAN E V et al.Effect of NASA light-emitting diode irradiation on wound healing[J].Journal of Clinical Laser Medicine and Surgery,2001,19(6):305～341.
[4]	WHELAN H T,BUCHMANN E V,WHELAN N T et al.NASA light emitting diode medical applications from deep space to deep sea[A].Space Technology and Applications International Forum[C].Melville,New York:American Institute of Physics,2001.35～45.
[5]	WHELAN H T,SCHMIDT M H,SEGURA A D et al.The role of photodynamic therapy in posterior fossa brain tumors:a pre-clinical study in a canine glioma model[J].Journal of Neurosurgery,1993,79(4):562～568.
[6]	WHELAN H T,MARGARET T T,RILEY W et al.DARPA soldier self care:rapid healing of laser eye injuries with light emitting diode technology[A].RTO HFM Symposium[C].Northern Mariana Islands:Trauma Technology and Emergency Medical Procedures,2004.19～37.
[7]	WHELAN H T,HOULE J M,DONOHOE D L et al.Medical applications of space light-emitting diode technology-space station and beyond[A].Space Technology and Applictions International Forum[C].Melville,Yew York:American institute of Physics,1999.3～15.
[8]	LI Y,LIU T C Y,DUAN R et al.Effects of some anesthetics on wound healing:laser biomodulation mechanism[J].Lasers in Surgery and Medicine,2001,S13(7):7～15.
[9]	DUAN R,ZHU L,LIU T C Y et al.Light emitting diode irradiation protect against the amyloid beta 25-35 iduced apoptosis of PC12 cell in vitro[J].Lasers in Surgery and Medicine,2003,33 (3):199～203.
[10]	VREMAN H J,STEVENSON D K.Devices for treating circadian rhythm disorders using LED's[P].U S Patent:6350275,2002-09-15.
[11]	FRENKEL R E,FRENKEL B G.Quantifying stress reduction and medical treatment as a result of colored light therapies[P].U S Patent:6007569,1999-07-13.
[12]	VREMAN H J,SEIDMAN D S,STEVENSON D K.Phototherapy of jaundiced newborns using garments containing semiconductor lightemitting devices[P].U S Patent:6596016,2003-06-22.
[13]	ZHANG Ch M,WANG J,DU L Zh.Blue light source in phototherapy[J].Journal of Zhejiang University(Medical Sciences),2002,31 (3):222～224(in Chinese)
[14]	SCHLAGER K J.Immunophototherapy for the treatment of cancer of the larynx[J].SPIE,1993,1891:148～159.
[15]	XU Ch Sh,LEUNG W N.Study of hypericin-mediated photodynamic therapy on human nasopharyngeal carcinoma cell[J].Laser Technology,2005,29(4):395～397 (in Chinese).
[16]	MESTER E,SPIRY T,SZENDE B et al.Effect of laser rays on wound healing[J].The American Journal of Surgery,1971,22(8):532～535.
[17]	SCHMIDT M H,BAJIC D M,REICHERT K W et al.Light-emitting diodes as a light source for intra-operative photodynamic therapy[J].Neurosurgery,1996,38 (3):552～556.
[18]	FRANKA S,STEPHEN H A,KLAUS D J et al.Light-emitting diode (LED) polymerisation of dental composites:flexural properties and polymerisation potential[J].Biomaterials,2000,21 (5):1379～1385.
[19]	PERRICONE N V.Skin treatments using blue and violet light[P].U S Patent:20030009158A1,2003-07-22.
[20]	ELLA S.System and method for facial treatment[P].U S Patent:20030032900A1,2003-02-02.
[21]	ROBERT A W,DAVID H M,ROY G G et al.Clinical trial of novel non-thermal LED array for reversal of photoaging:clinical,histologic,and surface profilometric results[J].Lasers in Surgery and Medicine,2005,36(7):85～91.
[22]	STREETER J.Low level light therapy for the treatment of myocardial infarction[P].U S Patent:20030212442A1,2003-05-23.
[23]	STREETER J.Low level light therapy for the treatment of stroke[P].U S Patent:20030109906A1,2003-03-11.
[24]	SCHLAGER K J,LGNATIUS R W.An LED-array light source for medical therapy[J].SPIE,1994,2131:341～353.
[25]	LIU J,LIU T C Y.The applications and prospects of light emitting diodes in biology and medicine[J].Laser Journal,2002,23 (6):1～4(in Chinese).
[26]	LIU J,LIU T C Y,FAN G H.The light emitting diode (LED) instrument of low intensity irradiation of cellor tissue culture[J].Laser Journal,2003,24(4):78～80(in Chinese).
[27]	LIU J,FAN G H,LIU T C Y et al.The light emitting diode(LED) instrument of high intensity irradiation of cellor tissue culture[J].Acta Laser Biology Sinica,2003,12(4):308～314(in Chinese).

The development of light emitting diode therapy in biology and medicine

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Proportional views