Fabrication of hard bone scaffold molds using selective laser curing technology

LIU Fwu-hsing; NI Tsui-yen; LIAO Yunn-shiuan

doi:10.3969/j.issn.1001-3806.2010.06.012

Volume 34 Issue 6

Mar. 2011

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Fabrication of hard bone scaffold molds using selective laser curing technology

1.
Graduate School of Engineering Technology, Lunghwa University of Science and Technology, Taoyuan 33306, Taiwan, China;
2.
Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan, China

Received Date: 2009-12-29
Accepted Date: 2010-04-01

Abstract

In order to fabricate a porous hard bone scaffold mold with biological compatibility,it was made of hydroxyapatite based bioceramic because of the viscosity and support effect of bioceramic slurry.Then the microstructure of the solidified scaffolds after laser sintering and high-temperature post-process was observed with a scanning electron microscope.Furthermore, the surface roughness was measured with an atomic force microscope.The results show that the density and the surface finish of scaffolds can be increased after post process,which is good for the attachment and growth of osteoblast-like cells.
- laser technique,
- rapid prototyping,
- hydroxyapatite,
- bone scaffold

References

[1]	COOPER K G.Rapid prototyping technology:selection and application,mechanical engineering[M].New York:Marcel Dekker,2001:1-4.
[2]	JACOBS P F.Rapid prototyping manufacturing fundamentals of stereo-lithography[M].New York:Scociety of Manufacturing Engineers,1992:381-416.
[3]	HUANG J P.Using FCDM system for fabricating tissue engineering scaffolds[D].Taipei:Central University,2005:5-14(in Chinese).
[4]	HULBERT S F,BOKROS J C,HENCH L L,et al.Ceramics in clinical applications,past,present and future[M].Amsterdam:Elsevier Science Publishers,1987:3-27.
[5]	CHIANG Y W.Application of orous oly(L-lactide)/hydroxyapatite composites as bioabsorbable materials:preparation and its properties[D].Taipei:Taipei Medical University Institutional Reposity,2000:1-12(in Chinese).
[6]	PENG R Sh,WANG J B,YAO Q Zh.Application study of rapid prototyping manufacturing in medical[J].Chinese Journal of Lasers,2005,29(3):87-88(in Chinese).
[7]	CHUA C K,LEONG K F,LIM C S.Rapid prototyping:principles and applications[M].2nd ed.Singapore:World Scientific Publishing Company,2003:35-193.
[8]	ZHANG J H,ZHAO J F,TIAN Z J,et al.Experimental research of selective laser sintering of nano-Al2O3[J].Chinese Journal of Lasers,2004,28(5):455-458(in Chinese).
[9]	ZHU L Q.The principle and advantage of an innovative line scanning SLS RP system[J].Chinese Journal of Lasers,2002,22(3):305-308(in Chinese).
[10]	CHAI C S,BEN-NISSAN B.Bioactive nanocrystalline sol-gel hydroxyapatite coating[J].Journal of Materials Science:Materials in Medicine,1999,10(8):465-469.
[11]	SUN J S,TSUANG Y H,LIAO C J,et al.The effects of calcium phosphate particles on the frowth of osteoblasts[J].Journal of Biomedical Materials Research,1997,37(3):324-334(in Chinese).
[12]	RATNER B D,HOFFMAN A S,SCHOEN F J,et al.Biomaterials science-an introduction to materials in medicine[M].San Diego:Academic Press,1996:105-118.
[13]	de GROOT K.Bioceramics of calcium phosphate[M].Florida:CRC Press,1983:79-97.
[14]	KIM S S,UTSUNOMIYA H,KOSKI J A,et al.Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels[J].Annals of Surgery,1998,228(1):8-13.
[15]	ZELTINGER J,SHERWOOD J K,GRAHAM D A,et al.Effect of pore size and void fraction on cellular adhesion,proliferation,and matrix deposition[J].Tissue Engineering,2001,7(5):557-572.
[16]	ZEIN I,DIETMAR W H,KIM Ch T,et al.Fused deposition modeling of novel scaffold architectures for tissue engineering applications[J].Biomaterials,2002,23(4):1169-1185.
[17]	KALITA S J,BOSE S,HOSICK H L,et al.Development of controlled porosity polymer-ceramic composite scaffolds via fused deposition modeling[J].Materials Science and Engineering,2003,C23(5):611-620.
[18]	XIONG Zh,YAN Y N,WANG Sh G,et al.Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition[J].Scripta Materialia,2002,11(7):771-776.
[19]	AUG T H,SULTANA F S A,HUTMACHER D W,et al.Fabrication of 3-D chitosan-hydroxyapatite scaffolds using a robotic dispensing system[J].Materials Science and Engineering,2002,C20(1/2):35-42.
[20]	MA B G,LIN L L,HUANG X X,et al.Bone tissue engineering using β-tricalcium phosphate scaffolds fabricated via selecting laser sintering[J].International Federation for Information Processing,2006,207:710-716.
[21]	WILLIAMS J M,ADEWUNMI A,SCHEK R M,et al.Bone tissue engineering using polycaprolactone scaffold fabricated via selective laser sintering[J].Biomaterials,2005,26(23):4817-4827.
[22]	LAM C X F,MO X M,TEOH S H,et al.Scaffold development using 3-D printing with a starch-based polymer[J].Materials Science and Engineering,2002,C20(1/2):49-56.
[23]	LIU F H.Method and equipment of forming porous bio-ceramic bone scaffold:Taiwan,098135507[P].2009(in Chinese).
[24]	DELIGIANNI D D,KATSALA N D,KOUTSOUKOS P G,et al.Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion,proliferation,differentiation and detachment strength[J].Biomaterials,2001,22(1):87-96.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Fabrication of hard bone scaffold molds using selective laser curing technology

1. Graduate School of Engineering Technology, Lunghwa University of Science and Technology, Taoyuan 33306, Taiwan, China;

2. Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan, China

Received Date: 2009-12-29

Accepted Date: 2010-04-01

Available Online: 2010-11-25

Abstract: In order to fabricate a porous hard bone scaffold mold with biological compatibility,it was made of hydroxyapatite based bioceramic because of the viscosity and support effect of bioceramic slurry.Then the microstructure of the solidified scaffolds after laser sintering and high-temperature post-process was observed with a scanning electron microscope.Furthermore, the surface roughness was measured with an atomic force microscope.The results show that the density and the surface finish of scaffolds can be increased after post process,which is good for the attachment and growth of osteoblast-like cells.

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Reference (24)

[1]	COOPER K G.Rapid prototyping technology:selection and application,mechanical engineering[M].New York:Marcel Dekker,2001:1-4.
[2]	JACOBS P F.Rapid prototyping manufacturing fundamentals of stereo-lithography[M].New York:Scociety of Manufacturing Engineers,1992:381-416.
[3]	HUANG J P.Using FCDM system for fabricating tissue engineering scaffolds[D].Taipei:Central University,2005:5-14(in Chinese).
[4]	HULBERT S F,BOKROS J C,HENCH L L,et al.Ceramics in clinical applications,past,present and future[M].Amsterdam:Elsevier Science Publishers,1987:3-27.
[5]	CHIANG Y W.Application of orous oly(L-lactide)/hydroxyapatite composites as bioabsorbable materials:preparation and its properties[D].Taipei:Taipei Medical University Institutional Reposity,2000:1-12(in Chinese).
[6]	PENG R Sh,WANG J B,YAO Q Zh.Application study of rapid prototyping manufacturing in medical[J].Chinese Journal of Lasers,2005,29(3):87-88(in Chinese).
[7]	CHUA C K,LEONG K F,LIM C S.Rapid prototyping:principles and applications[M].2nd ed.Singapore:World Scientific Publishing Company,2003:35-193.
[8]	ZHANG J H,ZHAO J F,TIAN Z J,et al.Experimental research of selective laser sintering of nano-Al2O3[J].Chinese Journal of Lasers,2004,28(5):455-458(in Chinese).
[9]	ZHU L Q.The principle and advantage of an innovative line scanning SLS RP system[J].Chinese Journal of Lasers,2002,22(3):305-308(in Chinese).
[10]	CHAI C S,BEN-NISSAN B.Bioactive nanocrystalline sol-gel hydroxyapatite coating[J].Journal of Materials Science:Materials in Medicine,1999,10(8):465-469.
[11]	SUN J S,TSUANG Y H,LIAO C J,et al.The effects of calcium phosphate particles on the frowth of osteoblasts[J].Journal of Biomedical Materials Research,1997,37(3):324-334(in Chinese).
[12]	RATNER B D,HOFFMAN A S,SCHOEN F J,et al.Biomaterials science-an introduction to materials in medicine[M].San Diego:Academic Press,1996:105-118.
[13]	de GROOT K.Bioceramics of calcium phosphate[M].Florida:CRC Press,1983:79-97.
[14]	KIM S S,UTSUNOMIYA H,KOSKI J A,et al.Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels[J].Annals of Surgery,1998,228(1):8-13.
[15]	ZELTINGER J,SHERWOOD J K,GRAHAM D A,et al.Effect of pore size and void fraction on cellular adhesion,proliferation,and matrix deposition[J].Tissue Engineering,2001,7(5):557-572.
[16]	ZEIN I,DIETMAR W H,KIM Ch T,et al.Fused deposition modeling of novel scaffold architectures for tissue engineering applications[J].Biomaterials,2002,23(4):1169-1185.
[17]	KALITA S J,BOSE S,HOSICK H L,et al.Development of controlled porosity polymer-ceramic composite scaffolds via fused deposition modeling[J].Materials Science and Engineering,2003,C23(5):611-620.
[18]	XIONG Zh,YAN Y N,WANG Sh G,et al.Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition[J].Scripta Materialia,2002,11(7):771-776.
[19]	AUG T H,SULTANA F S A,HUTMACHER D W,et al.Fabrication of 3-D chitosan-hydroxyapatite scaffolds using a robotic dispensing system[J].Materials Science and Engineering,2002,C20(1/2):35-42.
[20]	MA B G,LIN L L,HUANG X X,et al.Bone tissue engineering using β-tricalcium phosphate scaffolds fabricated via selecting laser sintering[J].International Federation for Information Processing,2006,207:710-716.
[21]	WILLIAMS J M,ADEWUNMI A,SCHEK R M,et al.Bone tissue engineering using polycaprolactone scaffold fabricated via selective laser sintering[J].Biomaterials,2005,26(23):4817-4827.
[22]	LAM C X F,MO X M,TEOH S H,et al.Scaffold development using 3-D printing with a starch-based polymer[J].Materials Science and Engineering,2002,C20(1/2):49-56.
[23]	LIU F H.Method and equipment of forming porous bio-ceramic bone scaffold:Taiwan,098135507[P].2009(in Chinese).
[24]	DELIGIANNI D D,KATSALA N D,KOUTSOUKOS P G,et al.Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion,proliferation,differentiation and detachment strength[J].Biomaterials,2001,22(1):87-96.

Fabrication of hard bone scaffold molds using selective laser curing technology

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通讯作者: 陈斌, bchen63@163.com

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Fabrication of hard bone scaffold molds using selective laser curing technology

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